Any of a variety of conditions that are characterized by significant impairment of brain tissue and resultant loss of brain function including degenerative illnesses (e.g., Alzheimer's disease, multiple sclerosis, Parkinson's disease, stroke and other cerebrovascular accidents), genetic variations or mutations that affect the development and functioning of the brain either in utero or following birth, traumatic brain injury, post infection damage, brain tumours, and permanent damage that occurs as a result of seizures, substance toxicity or other disorders as well as conditions affecting the brain that are present prior to birth.

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The parents, children, spouses, partners, friends or other relatives or significant others of people who have Alzheimer's disease or a related dementia, whose own patterns of personal, social and familial coping have been significantly affected by concern about the individual.

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